Cargando…

Normal Ranges of Thiopurine Methyltransferase Activity Do Not Affect Thioguanine Nucleotide Concentrations With Azathioprine Therapy in Inflammatory Bowel Disease

BACKGROUND: Thiopurine methyltransferase (TPMT) activity influences azathioprine conversion into active metabolite 6-thioguanine nucleotide (6-TGN). Low TPMT activity correlates with high 6-TGN and risk for myelosuppression. Conversely, normal-to-high TPMT activity may be associated with low 6-TGN a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jonason, David E, Sievers, Tyson, Trocke, Lindsay, Abraham, James M, Vaughn, Byron P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Observations and Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802184/ https://www.ncbi.nlm.nih.gov/pubmed/36776499 http://dx.doi.org/10.1093/crocol/otaa058

Ejemplares similares

Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine
por: Bayoumy, Ahmed B., et al.
Publicado: (2021)

Thiopurine Methyltransferase Predicts the Extent of Cytotoxicty and DNA Damage in Astroglial Cells after Thioguanine Exposure
por: Hosni-Ahmed, Amira, et al.
Publicado: (2011)

Thiopurine S-Methyltransferase Polymorphisms Predict Hepatotoxicity in Azathioprine-Treated Patients with Autoimmune Diseases
por: Sheu, Heh-Shiang, et al.
Publicado: (2022)

Concomitant 5-aminosalicylic acid treatment does not affect 6-thioguanine nucleotide levels in patients with inflammatory bowel disease on thiopurines
por: Looser, Rahel, et al.
Publicado: (2023)

Thiopurine Methyltransferase Activity and Thiopurine Metabolites in Inflammatory Bowel Disease
por: El-Matary, Wael
Publicado: (2020)

Thiopurine methyltransferase genotype and thiopurine S-methyltransferase activity in Greek children with inflammatory bowel disease
por: Gazouli, Μaria, et al.
Publicado: (2012)

Association of thiopurine S-methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease
por: Su, Song-Sen, et al.
Publicado: (2020)

Usefulness of Measuring Thiopurine Metabolites in Children with Inflammatory Bowel Disease and Autoimmunological Hepatitis, Treated with Azathioprine
por: Bąk-Drabik, Katarzyna, et al.
Publicado: (2021)

Pharmacogenetics of thiopurine therapy: from thiopurine S-methyltransferase to S-adenosylmethionine
por: Mlinarič-Raščan, Irena, et al.
Publicado: (2009)

Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines
por: Kojima, Yuichiro, et al.
Publicado: (2018)

Azathioprine monotherapy withdrawal in inflammatory bowel diseases: A retrospective mono-centric study
por: Crepaldi, Martina, et al.
Publicado: (2023)

Increments in DNA-thioguanine level during thiopurine-enhanced maintenance therapy of acute lymphoblastic leukemia
por: Larsen, Rikke Hebo, et al.
Publicado: (2021)

Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study
por: Hessels, Arno C., et al.
Publicado: (2018)

Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis
por: Liu, Yue-Ping, et al.
Publicado: (2015)

Bone marrow inhibition induced by azathioprine in a patient without mutation in the thiopurine S-methyltransferase pathogenic site: A case report
por: Zhou, Xiao-Shuang, et al.
Publicado: (2021)

Psychological Features in the Inflammatory Bowel Disease–Irritable Bowel Syndrome Overlap: Developing a Preliminary Understanding of Cognitive and Behavioral Factors
por: Petrik, Megan, et al.
Publicado: (2021)

Nurse-Provided Medication Guidance for Improving Drug Adherence to Thiopurines in Outpatients With Inflammatory Bowel Disease: A Single-Center Prospective Study
por: Shinzaki, Shinichiro, et al.
Publicado: (2021)

Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease
por: Gupta, Neera, et al.
Publicado: (2018)

Association between Thiopurine S-methyltransferase Polymorphisms and Thiopurine-Induced Adverse Drug Reactions in Patients with Inflammatory Bowel Disease: A Meta-Analysis
por: Liu, Yue-Ping, et al.
Publicado: (2015)

Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease Patients
por: Ribaldone, Davide Giuseppe, et al.
Publicado: (2019)

Thiopurine S-methyltransferase genetic polymorphisms in adult patients with inflammatory bowel diseases in the Latvian population
por: Zalizko, Polina, et al.
Publicado: (2020)

Pharmacogenetic studies of thiopurine methyltransferase genotype‐phenotype concordance and effect of methotrexate on thiopurine metabolism
por: Zimdahl Kahlin, Anna, et al.
Publicado: (2020)

Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity
por: Daniel, Laura L., et al.
Publicado: (2022)

Excited-State Dynamics of the Thiopurine Prodrug 6-Thioguanine: Can N9-Glycosylation Affect Its Phototoxic Activity?
por: Ashwood, Brennan, et al.
Publicado: (2017)

Thiopurine S-Methyltransferase and Methylenetetrahydrofolate Reductase Polymorphisms in Leukemia
por: KÜPELİ, Serhan
Publicado: (2015)

Thiopurine S-Methyltransferase Polymorphisms in Korean Dermatologic Patients
por: Lee, Minseok, et al.
Publicado: (2017)

Assessment of Thiopurine–based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia
por: Azimi, F, et al.
Publicado: (2014)

Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics
por: Lennard, Lynne, et al.
Publicado: (2014)

Thiopurine Exposure During Pregnancy is Not Associated With Anemia in Infants Born to Mothers With IBD
por: Yeaman, Fiona, et al.
Publicado: (2023)

Thiopurines in Inflammatory Bowel Disease. How to Optimize Thiopurines in the Biologic Era?
por: Gargallo-Puyuelo, Carla J., et al.
Publicado: (2021)

Real-World Long-Term Remission Maintenance for 10 Years With Thiopurines in Ulcerative Colitis
por: Matsumoto, Satohiro, et al.
Publicado: (2021)

Nonalcoholic Fatty Liver Disease Is a Risk Factor for Thiopurine Hepatotoxicity in Crohn’s Disease
por: George, Alvin T, et al.
Publicado: (2023)

Association between 6-thioguanine nucleotide levels and preventing production of antibodies to infliximab in patients with inflammatory bowel disease
por: Phillips, Jennifer, et al.
Publicado: (2023)

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk
por: Nguyen, Christine M., et al.
Publicado: (2011)

Polymorphisms of the thiopurine S-methyltransferase gene among the Libyan population
por: Zeglam, Hamza Ben, et al.
Publicado: (2015)

Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia
por: Linga, Vijay Gandhi, et al.
Publicado: (2014)

Utility of Maternal 6-Thioguanine Nucleotide Levels in Predicting Neonatal Pancytopenia
por: Maruyama, Hidehiko, et al.
Publicado: (2012)

Quantification of Thioguanine in DNA Using Liquid Chromatography-Tandem Mass Spectrometry for Routine Thiopurine Drug Monitoring in Patients With Pediatric Acute Lymphoblastic Leukemia
por: Choi, Rihwa, et al.
Publicado: (2021)

Thiopurine S-methyltransferase activity in Nigerians: phenotypes and activity reference values
por: Adehin, Ayorinde, et al.
Publicado: (2018)

Thiopurine S-methyltransferase and Pemphigus Vulgaris: A Phenotype-Genotype Study
por: Mokhtari, Maral, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_grtgcnagud454d417d6ulttt2g