Structural basis for p53 binding to its nucleosomal target DNA sequence

The tumor suppressor p53 functions as a pioneer transcription factor that binds a nucleosomal target DNA sequence. However, the mechanism by which p53 binds to its target DNA in the nucleosome remains elusive. Here we report the cryo-electron microscopy structures of the p53 DNA-binding domain and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Nishimura, Masahiro, Takizawa, Yoshimasa, Nozawa, Kayo, Kurumizaka, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802185/
https://www.ncbi.nlm.nih.gov/pubmed/36714865
http://dx.doi.org/10.1093/pnasnexus/pgac177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802185/
https://www.ncbi.nlm.nih.gov/pubmed/36714865
http://dx.doi.org/10.1093/pnasnexus/pgac177

Ejemplares similares