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Structural basis for p53 binding to its nucleosomal target DNA sequence

The tumor suppressor p53 functions as a pioneer transcription factor that binds a nucleosomal target DNA sequence. However, the mechanism by which p53 binds to its target DNA in the nucleosome remains elusive. Here we report the cryo-electron microscopy structures of the p53 DNA-binding domain and t...

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Detalles Bibliográficos
Autores principales:	Nishimura, Masahiro, Takizawa, Yoshimasa, Nozawa, Kayo, Kurumizaka, Hitoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Biological, Health, and Medical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802185/ https://www.ncbi.nlm.nih.gov/pubmed/36714865 http://dx.doi.org/10.1093/pnasnexus/pgac177

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