A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5

MEK inhibitors are among the most successful molecularly targeted agents used as cancer therapeutics. However, to treat cancer more efficiently, resistance to MEK inhibitor-induced cell death must be overcome. Although previous genetic approaches based on comprehensive gene expression analysis or RN...

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Detalles Bibliográficos
Autores principales: Watanabe, Motoki, Boku, Shogen, Kobayashi, Kaito, Kurumida, Yoichi, Sukeno, Mamiko, Masuda, Mitsuharu, Mizushima, Katsura, Kato, Chikage, Iizumi, Yosuke, Hirota, Kiichi, Naito, Yuji, Mutoh, Michihiro, Kameda, Tomoshi, Sakai, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802315/
https://www.ncbi.nlm.nih.gov/pubmed/36713317
http://dx.doi.org/10.1093/pnasnexus/pgac059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802315/
https://www.ncbi.nlm.nih.gov/pubmed/36713317
http://dx.doi.org/10.1093/pnasnexus/pgac059

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