Intratumoral nanobody–IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice

Confining cytokine exposure to the tumors would greatly enhance cancer immunotherapy safety and efficacy. Immunocytokines, cytokines fused to tumor-targeting antibodies, have been developed with this intention, but without significant clinical success to date. A critical limitation is uptake by rece...

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Detalles Bibliográficos
Autores principales: Lutz, Emi A, Jailkhani, Noor, Momin, Noor, Huang, Ying, Sheen, Allison, Kang, Byong H, Wittrup, K Dane, Hynes, Richard O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802395/
https://www.ncbi.nlm.nih.gov/pubmed/36712341
http://dx.doi.org/10.1093/pnasnexus/pgac244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802395/
https://www.ncbi.nlm.nih.gov/pubmed/36712341
http://dx.doi.org/10.1093/pnasnexus/pgac244

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