Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis

Ewing sarcoma (EwS) is a human malignant tumor typically driven by the Ewing sarcoma-Friend leukemia integration (EWS-FLI) fusion protein. A paucity of genetically modified animal models, partially owed to the high toxicity of EWS-FLI, hinders research on EwS. Here, we report a spontaneous mutant va...

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Detalles Bibliográficos
Autores principales: Molnar, Cristina, Reina, Jose, Herrero, Anastasia, Heinen, Jan Peter, Méndiz, Victoria, Bonnal, Sophie, Irimia, Manuel, Sánchez-Jiménez, María, Sánchez-Molina, Sara, Mora, Jaume, Gonzalez, Cayetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802468/
https://www.ncbi.nlm.nih.gov/pubmed/36714878
http://dx.doi.org/10.1093/pnasnexus/pgac222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802468/
https://www.ncbi.nlm.nih.gov/pubmed/36714878
http://dx.doi.org/10.1093/pnasnexus/pgac222

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