Targeting an evolutionarily conserved “E-L-L” motif in spike protein to identify a small molecule fusion inhibitor against SARS-CoV-2

As newer variants of SARS-CoV-2 continue to pose major threats to global human health and economy, identifying novel druggable antiviral targets is the key toward sustenance. Here, we identify an evolutionarily conserved “Ex(3)Lx(6)L” (“E-L-L”) motif present within the HR2 domain of all human and no...

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Detalles Bibliográficos
Autores principales: Jana, Indrani Das, Bhattacharya, Prabuddha, Mayilsamy, Karthick, Banerjee, Saptarshi, Bhattacharje, Gourab, Das, Sayan, Aditya, Seemanti, Ghosh, Anandita, McGill, Andrew R, Srikrishnan, Syamanthak, Das, Amit Kumar, Basak, Amit, Mohapatra, Shyam S, Chandran, Bala, Bhimsaria, Devesh, Mohapatra, Subhra, Roy, Arunava, Mondal, Arindam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802491/
https://www.ncbi.nlm.nih.gov/pubmed/36712339
http://dx.doi.org/10.1093/pnasnexus/pgac198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802491/
https://www.ncbi.nlm.nih.gov/pubmed/36712339
http://dx.doi.org/10.1093/pnasnexus/pgac198

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