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Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging
PARP1 contributes to genome architecture and DNA damage repair through its dynamic association with chromatin. PARP1 and PARP2 (PARP1/2) recognize damaged DNA and recruit the DNA repair machinery. Using single-molecule microscopy in live cells, we monitored the movement of PARP1/2 on undamaged and d...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804145/ https://www.ncbi.nlm.nih.gov/pubmed/36594010 http://dx.doi.org/10.1016/j.isci.2022.105779 |