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Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging

PARP1 contributes to genome architecture and DNA damage repair through its dynamic association with chromatin. PARP1 and PARP2 (PARP1/2) recognize damaged DNA and recruit the DNA repair machinery. Using single-molecule microscopy in live cells, we monitored the movement of PARP1/2 on undamaged and d...

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Detalles Bibliográficos
Autores principales:	Mahadevan, Jyothi, Jha, Asmita, Rudolph, Johannes, Bowerman, Samuel, Narducci, Domenic, Hansen, Anders S., Luger, Karolin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804145/ https://www.ncbi.nlm.nih.gov/pubmed/36594010 http://dx.doi.org/10.1016/j.isci.2022.105779

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