Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition

BACKGROUND AND PURPOSE: Statins, inhibitors of HMG‐CoA reductase, are mainstay treatment for hypercholesterolaemia. However, muscle pain and weakness prevent many patients from benefiting from their cardioprotective effects. We previously demonstrated that simvastatin activates skeletal ryanodine re...

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Detalles Bibliográficos
Autores principales: Lindsay, Chris, Musgaard, Maria, Russell, Angela J., Sitsapesan, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804224/
https://www.ncbi.nlm.nih.gov/pubmed/35703154
http://dx.doi.org/10.1111/bph.15893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804224/
https://www.ncbi.nlm.nih.gov/pubmed/35703154
http://dx.doi.org/10.1111/bph.15893

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