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Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition
BACKGROUND AND PURPOSE: Statins, inhibitors of HMG‐CoA reductase, are mainstay treatment for hypercholesterolaemia. However, muscle pain and weakness prevent many patients from benefiting from their cardioprotective effects. We previously demonstrated that simvastatin activates skeletal ryanodine re...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804224/ https://www.ncbi.nlm.nih.gov/pubmed/35703154 http://dx.doi.org/10.1111/bph.15893 |