Improving cooperativity of transcription activators by oligomerization domains in mammalian cells

Cooperative activation is critical for the applications of synthetic biology in mammalian cells. In this study, we have developed cooperative transcription factor by fusing oligomerization domain in mammalian cells. Firstly, we demonstrated that two oligomerized domains (CI434 and CI) successfully i...

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Detalles Bibliográficos
Autores principales: Chen, Xinmao, Liu, Ziming, Lou, Chunbo, Guan, Ying, Ouyang, Qi, Xiang, Yanhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804245/
https://www.ncbi.nlm.nih.gov/pubmed/36605704
http://dx.doi.org/10.1016/j.synbio.2022.12.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804245/
https://www.ncbi.nlm.nih.gov/pubmed/36605704
http://dx.doi.org/10.1016/j.synbio.2022.12.003

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