Chemo‐ and Site‐Selective Electro‐Oxidative Alkane Fluorination by C(sp(3))−H Cleavage

Electrochemical fluorinations of C(sp(3))−H bonds with a nucleophilic fluoride source have been accomplished in a chemo‐ and site‐selective fashion, avoiding the use of electrophilic F(+) sources and stoichiometric oxidants. The introduced metal‐free strategy exhibits high functional group tolerance, setting the stage for late‐stage fluorinations of biorelevant motifs. The synthetic utility of the C(sp(3))−H fluorination was reflected by subsequent one‐pot arylation of the generated benzylic fluorides.