Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity

Plasmepsin X (PMX) is an aspartyl protease that processes proteins essential for Plasmodium parasites to invade and egress from host erythrocytes during the symptomatic asexual stage of malaria. PMX substrates possess a conserved cleavage region denoted by the consensus motif, SFhE (h=hydrophobic am...

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Detalles Bibliográficos
Autores principales: Richardson, Lachlan W., Ashton, Trent D., Dans, Madeline G., Nguyen, Nghi, Favuzza, Paola, Triglia, Tony, Hodder, Anthony N., Ngo, Anna, Jarman, Kate E., Cowman, Alan F., Sleebs, Brad E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804387/
https://www.ncbi.nlm.nih.gov/pubmed/35906744
http://dx.doi.org/10.1002/cmdc.202200306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804387/
https://www.ncbi.nlm.nih.gov/pubmed/35906744
http://dx.doi.org/10.1002/cmdc.202200306

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