The Importance of Mg(2+)‐Free State in Nucleotide Exchange of Oncogenic K‐Ras Mutants

For efficient targeting of oncogenic K‐Ras interaction sites, a mechanistic picture of the Ras‐cycle is necessary. Herein, we used NMR relaxation techniques and molecular dynamics simulations to decipher the role of slow dynamics in wild‐type and three oncogenic P‐loop mutants of K‐Ras. Our measurem...

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Detalles Bibliográficos
Autores principales: Pálfy, Gyula, Menyhárd, Dóra K., Ákontz‐Kiss, Hanna, Vida, István, Batta, Gyula, Tőke, Orsolya, Perczel, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804424/
https://www.ncbi.nlm.nih.gov/pubmed/35781716
http://dx.doi.org/10.1002/chem.202201449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804424/
https://www.ncbi.nlm.nih.gov/pubmed/35781716
http://dx.doi.org/10.1002/chem.202201449

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