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Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study

BACKGROUND: This study aimed to investigate the efficacy of surgery in the treatment of small cell carcinoma of the esophagus (SCCE) and explore potential prognostic factors. METHODS: We screened patients with SCCE who underwent esophagectomy from 2010 to 2018 at three institutes. Differences in sur...

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Autores principales: Gu, Yi‐Min, Yang, Yu‐Shang, Shi, Gui‐Dong, Yan, Cheng‐Yi, Shang, Qi‐Xin, Zhang, Han‐Lu, Wang, Wen‐Ping, Yuan, Yong, Chen, Long‐Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804522/
https://www.ncbi.nlm.nih.gov/pubmed/36036894
http://dx.doi.org/10.1002/jso.27073
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author Gu, Yi‐Min
Yang, Yu‐Shang
Shi, Gui‐Dong
Yan, Cheng‐Yi
Shang, Qi‐Xin
Zhang, Han‐Lu
Wang, Wen‐Ping
Yuan, Yong
Chen, Long‐Qi
author_facet Gu, Yi‐Min
Yang, Yu‐Shang
Shi, Gui‐Dong
Yan, Cheng‐Yi
Shang, Qi‐Xin
Zhang, Han‐Lu
Wang, Wen‐Ping
Yuan, Yong
Chen, Long‐Qi
author_sort Gu, Yi‐Min
collection PubMed
description BACKGROUND: This study aimed to investigate the efficacy of surgery in the treatment of small cell carcinoma of the esophagus (SCCE) and explore potential prognostic factors. METHODS: We screened patients with SCCE who underwent esophagectomy from 2010 to 2018 at three institutes. Differences in survival were analyzed using the Kaplan–Meier method and log–rank test. The prognostic factors were identified using univariate and multivariate analyses. RESULTS: A total of 69 patients were included. Multivariate analysis showed that TNM stage (hazard ratio [HR]: 4.10, 95% confidence interval [CI]: 1.57–10.75, p = 0.004) and adjuvant therapy (HR: 0.28, 95% CI: 0.16–0.51, p < 0.001) were independent prognostic factors. Stage I, stage IIA, and stage IIB disease were merged into the surgery response disease (SRD), whereas stage III disease into the surgery nonresponse disease (SNRD). The SRD group had significantly improved survival compared to the SNRD group (HR: 0.33, 95% CI: 0.19–0.58, p < 0.001). In addition, adjuvant therapy increased survival benefit in the SNRD group (p < 0.001) but not in the SRD group (p = 0.061). CONCLUSIONS: Surgery alone appears to be adequate for disease control in the SRD group, whereas multimodality therapy was associated with improved survival in the SNRD group.
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spelling pubmed-98045222023-01-03 Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study Gu, Yi‐Min Yang, Yu‐Shang Shi, Gui‐Dong Yan, Cheng‐Yi Shang, Qi‐Xin Zhang, Han‐Lu Wang, Wen‐Ping Yuan, Yong Chen, Long‐Qi J Surg Oncol Esophageal BACKGROUND: This study aimed to investigate the efficacy of surgery in the treatment of small cell carcinoma of the esophagus (SCCE) and explore potential prognostic factors. METHODS: We screened patients with SCCE who underwent esophagectomy from 2010 to 2018 at three institutes. Differences in survival were analyzed using the Kaplan–Meier method and log–rank test. The prognostic factors were identified using univariate and multivariate analyses. RESULTS: A total of 69 patients were included. Multivariate analysis showed that TNM stage (hazard ratio [HR]: 4.10, 95% confidence interval [CI]: 1.57–10.75, p = 0.004) and adjuvant therapy (HR: 0.28, 95% CI: 0.16–0.51, p < 0.001) were independent prognostic factors. Stage I, stage IIA, and stage IIB disease were merged into the surgery response disease (SRD), whereas stage III disease into the surgery nonresponse disease (SNRD). The SRD group had significantly improved survival compared to the SNRD group (HR: 0.33, 95% CI: 0.19–0.58, p < 0.001). In addition, adjuvant therapy increased survival benefit in the SNRD group (p < 0.001) but not in the SRD group (p = 0.061). CONCLUSIONS: Surgery alone appears to be adequate for disease control in the SRD group, whereas multimodality therapy was associated with improved survival in the SNRD group. John Wiley and Sons Inc. 2022-08-29 2022-12-15 /pmc/articles/PMC9804522/ /pubmed/36036894 http://dx.doi.org/10.1002/jso.27073 Text en © 2022 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided theoriginal work is p roperly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Esophageal
Gu, Yi‐Min
Yang, Yu‐Shang
Shi, Gui‐Dong
Yan, Cheng‐Yi
Shang, Qi‐Xin
Zhang, Han‐Lu
Wang, Wen‐Ping
Yuan, Yong
Chen, Long‐Qi
Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study
title Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study
title_full Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study
title_fullStr Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study
title_full_unstemmed Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study
title_short Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study
title_sort limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: a multicenter retrospective cohort study
topic Esophageal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804522/
https://www.ncbi.nlm.nih.gov/pubmed/36036894
http://dx.doi.org/10.1002/jso.27073
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