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Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study
BACKGROUND: This study aimed to investigate the efficacy of surgery in the treatment of small cell carcinoma of the esophagus (SCCE) and explore potential prognostic factors. METHODS: We screened patients with SCCE who underwent esophagectomy from 2010 to 2018 at three institutes. Differences in sur...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804522/ https://www.ncbi.nlm.nih.gov/pubmed/36036894 http://dx.doi.org/10.1002/jso.27073 |
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author | Gu, Yi‐Min Yang, Yu‐Shang Shi, Gui‐Dong Yan, Cheng‐Yi Shang, Qi‐Xin Zhang, Han‐Lu Wang, Wen‐Ping Yuan, Yong Chen, Long‐Qi |
author_facet | Gu, Yi‐Min Yang, Yu‐Shang Shi, Gui‐Dong Yan, Cheng‐Yi Shang, Qi‐Xin Zhang, Han‐Lu Wang, Wen‐Ping Yuan, Yong Chen, Long‐Qi |
author_sort | Gu, Yi‐Min |
collection | PubMed |
description | BACKGROUND: This study aimed to investigate the efficacy of surgery in the treatment of small cell carcinoma of the esophagus (SCCE) and explore potential prognostic factors. METHODS: We screened patients with SCCE who underwent esophagectomy from 2010 to 2018 at three institutes. Differences in survival were analyzed using the Kaplan–Meier method and log–rank test. The prognostic factors were identified using univariate and multivariate analyses. RESULTS: A total of 69 patients were included. Multivariate analysis showed that TNM stage (hazard ratio [HR]: 4.10, 95% confidence interval [CI]: 1.57–10.75, p = 0.004) and adjuvant therapy (HR: 0.28, 95% CI: 0.16–0.51, p < 0.001) were independent prognostic factors. Stage I, stage IIA, and stage IIB disease were merged into the surgery response disease (SRD), whereas stage III disease into the surgery nonresponse disease (SNRD). The SRD group had significantly improved survival compared to the SNRD group (HR: 0.33, 95% CI: 0.19–0.58, p < 0.001). In addition, adjuvant therapy increased survival benefit in the SNRD group (p < 0.001) but not in the SRD group (p = 0.061). CONCLUSIONS: Surgery alone appears to be adequate for disease control in the SRD group, whereas multimodality therapy was associated with improved survival in the SNRD group. |
format | Online Article Text |
id | pubmed-9804522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98045222023-01-03 Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study Gu, Yi‐Min Yang, Yu‐Shang Shi, Gui‐Dong Yan, Cheng‐Yi Shang, Qi‐Xin Zhang, Han‐Lu Wang, Wen‐Ping Yuan, Yong Chen, Long‐Qi J Surg Oncol Esophageal BACKGROUND: This study aimed to investigate the efficacy of surgery in the treatment of small cell carcinoma of the esophagus (SCCE) and explore potential prognostic factors. METHODS: We screened patients with SCCE who underwent esophagectomy from 2010 to 2018 at three institutes. Differences in survival were analyzed using the Kaplan–Meier method and log–rank test. The prognostic factors were identified using univariate and multivariate analyses. RESULTS: A total of 69 patients were included. Multivariate analysis showed that TNM stage (hazard ratio [HR]: 4.10, 95% confidence interval [CI]: 1.57–10.75, p = 0.004) and adjuvant therapy (HR: 0.28, 95% CI: 0.16–0.51, p < 0.001) were independent prognostic factors. Stage I, stage IIA, and stage IIB disease were merged into the surgery response disease (SRD), whereas stage III disease into the surgery nonresponse disease (SNRD). The SRD group had significantly improved survival compared to the SNRD group (HR: 0.33, 95% CI: 0.19–0.58, p < 0.001). In addition, adjuvant therapy increased survival benefit in the SNRD group (p < 0.001) but not in the SRD group (p = 0.061). CONCLUSIONS: Surgery alone appears to be adequate for disease control in the SRD group, whereas multimodality therapy was associated with improved survival in the SNRD group. John Wiley and Sons Inc. 2022-08-29 2022-12-15 /pmc/articles/PMC9804522/ /pubmed/36036894 http://dx.doi.org/10.1002/jso.27073 Text en © 2022 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided theoriginal work is p roperly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Esophageal Gu, Yi‐Min Yang, Yu‐Shang Shi, Gui‐Dong Yan, Cheng‐Yi Shang, Qi‐Xin Zhang, Han‐Lu Wang, Wen‐Ping Yuan, Yong Chen, Long‐Qi Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study |
title | Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study |
title_full | Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study |
title_fullStr | Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study |
title_full_unstemmed | Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study |
title_short | Limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: A multicenter retrospective cohort study |
title_sort | limited‐stage small cell carcinoma of the esophagus treated with curative esophagectomy: a multicenter retrospective cohort study |
topic | Esophageal |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804522/ https://www.ncbi.nlm.nih.gov/pubmed/36036894 http://dx.doi.org/10.1002/jso.27073 |
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