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Investigating the prediction of CpG methylation levels from SNP genotype data to help elucidate relationships between methylation, gene expression and complex traits
As popularised by PrediXcan (and related methods), transcriptome‐wide association studies (TWAS), in which gene expression is imputed from single‐nucleotide polymorphism (SNP) genotypes and tested for association with a phenotype, are a popular approach for investigating the role of gene expression...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804820/ https://www.ncbi.nlm.nih.gov/pubmed/35930604 http://dx.doi.org/10.1002/gepi.22496 |