Rational Tuning of the Reactivity of Three‐Membered Heterocycle Ring Openings via S(N)2 Reactions

The development of small‐molecule covalent inhibitors and probes continuously pushes the rapidly evolving field of chemical biology forward. A key element in these molecular tool compounds is the “electrophilic trap” that allows a covalent linkage with the target enzyme. The reactivity of this entit...

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Detalles Bibliográficos
Autores principales: Hansen, Thomas, Nin‐Hill, Alba, Codée, Jeroen D. C., Hamlin, Trevor A., Rovira, Carme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804865/
https://www.ncbi.nlm.nih.gov/pubmed/35896443
http://dx.doi.org/10.1002/chem.202201649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804865/
https://www.ncbi.nlm.nih.gov/pubmed/35896443
http://dx.doi.org/10.1002/chem.202201649

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