MiR‐27a downregulates 14‐3‐3θ, RUNX1, AF4, and MLL‐AF4, crucial drivers of blast transformation in t(4;11) leukemia cells

The chromosomal translocation t(4;11)(q21;q23), a hallmark of an aggressive form of acute lymphoblastic leukemia (ALL), encodes mixed‐lineage leukemia (MLL)‐AF4 oncogenic chimera that triggers aberrant transcription of genes involved in lymphocyte differentiation, including HOXA9 and MEIS1. The scaf...

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Detalles Bibliográficos
Autores principales: Fioretti, Tiziana, Zanobio, Mariateresa, Raia, Maddalena, Errichiello, Santa, Izzo, Barbara, Cattaneo, Fabio, Ammendola, Rosario, Cevenini, Armando, Esposito, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804920/
https://www.ncbi.nlm.nih.gov/pubmed/35981137
http://dx.doi.org/10.1002/cbf.3736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804920/
https://www.ncbi.nlm.nih.gov/pubmed/35981137
http://dx.doi.org/10.1002/cbf.3736

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