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CD137L and CD4 T cells limit BCL6‐expressing pre‐germinal center B cell expansion and BCL6‐driven B cell malignancy

Aberrant expression of the proto‐oncogene BCL6 is a driver of tumorigenesis in diffuse large B cell lymphoma (DLBCL). Mice overexpressing BCL6 from the B cell‐specific immunoglobulin heavy chain μ intron promoter (Iμ‐Bcl6 (Tg/+)) develop B cell lymphomas with features typical of human DLBCL. While t...

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Detalles Bibliográficos
Autores principales: Ding, Zhoujie, Quast, Isaak, Yan, Feng, Liao, Yang, Pitt, Catherine, O‐Donnell, Kristy, Robinson, Marcus J, Shi, Wei, Kallies, Axel, Zotos, Dimitra, Tarlinton, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805071/
https://www.ncbi.nlm.nih.gov/pubmed/35916066
http://dx.doi.org/10.1111/imcb.12578