Respiratory chain dysfunction in perifascicular muscle fibres in patients with dermatomyositis is associated with mitochondrial DNA depletion

AIMS: Patients with dermatomyositis (DM) suffer from reduced aerobic metabolism contributing to impaired muscle function, which has been linked to cytochrome c oxidase (COX) deficiency in muscle tissue. This mitochondrial respiratory chain dysfunction is typically seen in perifascicular regions, whi...

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Detalles Bibliográficos
Autores principales: Hedberg‐Oldfors, Carola, Lindgren, Ulrika, Visuttijai, Kittichate, Lööf, Daniel, Roos, Sara, Thomsen, Christer, Oldfors, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805229/
https://www.ncbi.nlm.nih.gov/pubmed/35894812
http://dx.doi.org/10.1111/nan.12841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805229/
https://www.ncbi.nlm.nih.gov/pubmed/35894812
http://dx.doi.org/10.1111/nan.12841

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