Knock down of TIMP-2 by siRNA and CRISPR/Cas9 mediates diverse cellular reprogramming of metastasis and chemosensitivity in ovarian cancer

BACKGROUND: The endogenous tissue inhibitor of metalloproteinase-2 (TIMP-2), through its homeostatic action on certain metalloproteinases, plays a vital role in remodelling extracellular matrix (ECM) to facilitate cancer progression. This study investigated the role of TIMP-2 in an ovarian cancer ce...

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Detalles Bibliográficos
Autores principales: Escalona, Ruth M., Chu, Simon, Kadife, Elif, Kelly, Jason K., Kannourakis, George, Findlay, Jock K., Ahmed, Nuzhat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805260/
https://www.ncbi.nlm.nih.gov/pubmed/36585738
http://dx.doi.org/10.1186/s12935-022-02838-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805260/
https://www.ncbi.nlm.nih.gov/pubmed/36585738
http://dx.doi.org/10.1186/s12935-022-02838-x

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