Cargando…

Knock down of TIMP-2 by siRNA and CRISPR/Cas9 mediates diverse cellular reprogramming of metastasis and chemosensitivity in ovarian cancer

BACKGROUND: The endogenous tissue inhibitor of metalloproteinase-2 (TIMP-2), through its homeostatic action on certain metalloproteinases, plays a vital role in remodelling extracellular matrix (ECM) to facilitate cancer progression. This study investigated the role of TIMP-2 in an ovarian cancer ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Escalona, Ruth M., Chu, Simon, Kadife, Elif, Kelly, Jason K., Kannourakis, George, Findlay, Jock K., Ahmed, Nuzhat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805260/ https://www.ncbi.nlm.nih.gov/pubmed/36585738 http://dx.doi.org/10.1186/s12935-022-02838-x

Ejemplares similares

TIMP-2 regulates proliferation, invasion and STAT3-mediated cancer stem cell-dependent chemoresistance in ovarian cancer cells
por: Escalona, Ruth M., et al.
Publicado: (2020)

Expression of TIMPs and MMPs in Ovarian Tumors, Ascites, Ascites-Derived Cells, and Cancer Cell Lines: Characteristic Modulatory Response Before and After Chemotherapy Treatment
por: Escalona, Ruth M., et al.
Publicado: (2022)

Paclitaxel-Induced Src Activation Is Inhibited by Dasatinib Treatment, Independently of Cancer Stem Cell Properties, in a Mouse Model of Ovarian Cancer
por: Kadife, Elif, et al.
Publicado: (2019)

The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression
por: Escalona, Ruth M., et al.
Publicado: (2018)

Knockdown of stem cell regulator Oct4A in ovarian cancer reveals cellular reprogramming associated with key regulators of cytoskeleton-extracellular matrix remodelling
por: Samardzija, Chantel, et al.
Publicado: (2017)

Knocking down Disease with siRNAs
por: Dykxhoorn, Derek M., et al.
Publicado: (2006)

Unique proteome signature of post-chemotherapy ovarian cancer ascites-derived tumor cells
por: Ahmed, Nuzhat, et al.
Publicado: (2016)

Knocking down barriers: advances in siRNA delivery
por: Whitehead, Kathryn A., et al.
Publicado: (2009)

Platinum-resistance in epithelial ovarian cancer: an interplay of epithelial–mesenchymal transition interlinked with reprogrammed metabolism
por: Leung, Dilys, et al.
Publicado: (2022)

Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods
por: Ahmed, Nuzhat, et al.
Publicado: (2020)

Determinants of resistance to VEGF-TKI and immune checkpoint inhibitors in metastatic renal cell carcinoma
por: Sharma, Revati, et al.
Publicado: (2021)

Momelotinib decreased cancer stem cell associated tumor burden and prolonged disease-free remission period in a mouse model of human ovarian cancer
por: Chan, Emily, et al.
Publicado: (2018)

CRISPR/Cas9-Mediated Gene Knock-Down in Post-Mitotic Neurons
por: Straub, Christoph, et al.
Publicado: (2014)

Protocols for marker-free gene knock-out and knock-down in Kluyveromyces marxianus using CRISPR/Cas9
por: Rajkumar, Arun S, et al.
Publicado: (2021)

Coalition of Oct4A and β1 integrins in facilitating metastasis in ovarian cancer
por: Samardzija, Chantel, et al.
Publicado: (2016)

Gold Nanoparticle Mediated Laser Transfection for Efficient siRNA Mediated Gene Knock Down
por: Heinemann, Dag, et al.
Publicado: (2013)

Knock-down of ELMO1 in Paediatric Rhabdomyosarcoma Cells by Nanoparticle Mediated siRNA Delivery
por: Huang, Xinyue, et al.
Publicado: (2016)

CRISPR/cas9, a novel genomic tool to knock down microRNA in vitro and in vivo
por: Chang, Hong, et al.
Publicado: (2016)

Knocking Down TMPRSS2-ERG Fusion Oncogene by siRNA Could be an Alternative Treatment to Flutamide
por: Urbinati, Giorgia, et al.
Publicado: (2016)

Targeted gene knock-in by CRISPR/Cas ribonucleoproteins in porcine zygotes
por: Park, Ki-Eun, et al.
Publicado: (2017)

In vitro and intrathecal siRNA mediated K(V)1.1 knock-down in primary sensory neurons
por: Baker, Mark D., et al.
Publicado: (2011)

Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing
por: Kumita, Wakako, et al.
Publicado: (2019)

An efficient method to enrich for knock-out and knock-in cellular clones using the CRISPR/Cas9 system
por: Niccheri, Francesca, et al.
Publicado: (2017)

Anti-proliferative action of vitamin D in MCF7 is still active after siRNA-VDR knock-down
por: Costa, José L, et al.
Publicado: (2009)

Optimized knock-in of point mutations in zebrafish using CRISPR/Cas9
por: Prykhozhij, Sergey V, et al.
Publicado: (2018)

Optimized knock-in of point mutations in zebrafish using CRISPR/Cas9
por: Prykhozhij, Sergey V, et al.
Publicado: (2018)

CRISPR/Cas9-induced knockout and knock-in mutations in Chlamydomonas reinhardtii
por: Shin, Sung-Eun, et al.
Publicado: (2016)

Generation of knock-in lampreys by CRISPR-Cas9-mediated genome engineering
por: Suzuki, Daichi G., et al.
Publicado: (2021)

Chemosensitization of cancer cells by siRNA using targeted nanogel delivery
por: Dickerson, Erin B, et al.
Publicado: (2010)

Recombinant Adenovirus siRNA Knocking Down the Ndufs4 Gene Alleviates Myocardial Apoptosis Induced by Oxidative Stress Injury
por: Wang, Beibei, et al.
Publicado: (2023)

Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary
por: Samardzija, Chantel, et al.
Publicado: (2012)

Knocking down mitochondrial iron transporter (MIT) reprograms primary and secondary metabolism in rice plants
por: Vigani, Gianpiero, et al.
Publicado: (2016)

Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice
por: Aida, Tomomi, et al.
Publicado: (2015)

RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency
por: Song, Jun, et al.
Publicado: (2016)

ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes
por: Yoshimi, Kazuto, et al.
Publicado: (2016)

CRISPR/Cas9-mediated knock-in of the murine Y chromosomal Sry gene
por: IMAIMATSU, Kenya, et al.
Publicado: (2018)

Generation of beta-lactoglobulin knock-out goats using CRISPR/Cas9
por: Zhou, Wenjun, et al.
Publicado: (2017)

Generation of Tβ4 knock-in Cashmere goat using CRISPR/Cas9
por: Li, Xiaocong, et al.
Publicado: (2019)

Optimization of the production of knock-in alleles by CRISPR/Cas9 microinjection into the mouse zygote
por: Raveux, Aurélien, et al.
Publicado: (2017)

Generation of VEGF knock-in Cashmere goat via the CRISPR/Cas9 system
por: Hu, Xiao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4i5kh4i6k6gh6h6vu4t3ed1e3m