Effect of Cholesterol Content of Lipid Composition in mRNA-LNPs on the Protein Expression in the Injected Site and Liver After Local Administration in Mice

Delivery of messenger RNA (mRNA) using lipid nanoparticles (LNPs) is expected to be applied to various diseases following the successful clinical use of the mRNA COVID-19 vaccines. This study aimed to evaluate the effect of the cholesterol molar percentage of mRNA-LNPs on protein expression in hepat...

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Detalles Bibliográficos
Autores principales: Kawaguchi, Maho, Noda, Marin, Ono, Akari, Kamiya, Mariko, Matsumoto, Makoto, Tsurumaru, Masako, Mizukami, Shusaku, Mukai, Hidefumi, Kawakami, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. on behalf of American Pharmacists Association. 2023
Materias:
Pharmaceutics, Drug Delivery and Pharmaceutical Technology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805379/
https://www.ncbi.nlm.nih.gov/pubmed/36596392
http://dx.doi.org/10.1016/j.xphs.2022.12.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805379/
https://www.ncbi.nlm.nih.gov/pubmed/36596392
http://dx.doi.org/10.1016/j.xphs.2022.12.026

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