Cargando…

VX-765 Alleviates β-Amyloid Deposition and Secondary Degeneration in the Ipsilateral Hippocampus and Ameliorates Cognitive Decline after Focal Cortical Infarction in Rats

Focal cortical infarction leads to secondary degeneration of the ipsilateral hippocampus, which is associated with poststroke cognitive impairment. VX-765 is a potent small-molecule caspase-1 inhibitor that protects against central nervous system diseases. The present study aimed to determine the pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Dawei, Ren, Aihui, Yang, Ying, Su, Jiayi, Liu, Libin, Zhuo, Wenyan, Liang, Yubin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805416/ https://www.ncbi.nlm.nih.gov/pubmed/36441377 http://dx.doi.org/10.1007/s12031-022-02088-6

Ejemplares similares

VX-765 reduces neuroinflammation after spinal cord injury in mice
por: Chen, Jing, et al.
Publicado: (2021)

Effect of VX-765 on the transcriptome profile of mice spinal cords with acute injury
por: Chen, Jing, et al.
Publicado: (2020)

VX-765 has a Protective Effect on Mice with Ovarian Injury Caused by Chemotherapy
por: Lee, Pingyin, et al.
Publicado: (2023)

The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway
por: Do Carmo, Helison, et al.
Publicado: (2018)

VX‐765 ameliorates renal injury and fibrosis in diabetes by regulating caspase‐1‐mediated pyroptosis and inflammation
por: Wen, Si, et al.
Publicado: (2021)

VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice
por: Sun, Zhezhe, et al.
Publicado: (2020)

VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction
por: Wu, Siyi, et al.
Publicado: (2021)

Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis
por: Jin, Ying, et al.
Publicado: (2022)

Liraglutide Ameliorates β-Amyloid Deposits and Secondary Damage in the Ipsilateral Thalamus and Sensory Deficits After Focal Cerebral Infarction in Rats
por: Zhu, Hui-Li, et al.
Publicado: (2018)

Cognitive trajectories of patients with focal ß-amyloid deposition
por: Kim, Si Eun, et al.
Publicado: (2021)

VX‐765 enhances autophagy of human umbilical cord mesenchymal stem cells against stroke‐induced apoptosis and inflammatory responses via AMPK/mTOR signaling pathway
por: Sun, Zhezhe, et al.
Publicado: (2020)

765. Epidemiological And Clinical Features Of Rickettsiosis
por: Hammami, Fatma, et al.
Publicado: (2020)

Multiple intracranial cavernomas with focal amyloid deposition – diagnostic pitfalls
por: Velnar, T., et al.
Publicado: (2011)

The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4(+) T cell depletion, viral load, and total HIV-1 DNA in HIV-1 infected humanized mice
por: Amand, Mathieu, et al.
Publicado: (2023)

Proliferation in the Alzheimer Hippocampus Is due to Microglia, Not Astroglia, and Occurs at Sites of Amyloid Deposition
por: Marlatt, Michael W., et al.
Publicado: (2014)

Space-Dependent Glia–Neuron Interplay in the Hippocampus of Transgenic Models of β-Amyloid Deposition
por: Lana, Daniele, et al.
Publicado: (2020)

Exam ref 70-765 provisioning SQL databases
por: D'Antoni, Joseph, et al.
Publicado: (2018)

Light and heavy chain deposition disease with focal amyloid deposition diagnosed with mass spectrometry: a case report
por: Shimamoto, Yuki, et al.
Publicado: (2023)

Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome
por: Grigorova, Monika, et al.
Publicado: (2022)

Clinical significance of focal ß-amyloid deposition measured by (18)F-flutemetamol PET
por: Kim, Si Eun, et al.
Publicado: (2020)

Axonal degeneration and amyloid pathology predict cognitive decline beyond cortical atrophy
por: Svenningsson, Anna Linnéa, et al.
Publicado: (2022)

Degeneration of the Substantia Nigra Following Ipsilateral Striatal Infarction
por: Ohtomo, Gaku, et al.
Publicado: (2017)

Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline
por: Cole, James H., et al.
Publicado: (2017)

Beta amyloid deposition and cognitive decline in Parkinson’s disease: a study of the PPMI cohort
por: Mihaescu, Alexander S., et al.
Publicado: (2022)

Patterns of Focal Amyloid Deposition Using (18)F-Florbetaben PET in Patients with Cognitive Impairment
por: Chung, Sung-eun, et al.
Publicado: (2022)

THE DETECTION OF A VIRAL INTERFERING SUBSTANCE IN THE SHOPE PAPILLOMA AND THE Vx7 AND Vx2 CARCINOMAS
por: Langston, Deborah Pavan, et al.
Publicado: (1967)

Inhibition of Cathepsins B Induces Neuroprotection Against Secondary Degeneration in Ipsilateral Substantia Nigra After Focal Cortical Infarction in Adult Male Rats
por: Zuo, Xialin, et al.
Publicado: (2018)

L-765,314 Suppresses Melanin Synthesis by Regulating Tyrosinase Activity
por: Kim, Jinhwan, et al.
Publicado: (2019)

Focal-type, but not Diffuse-type, Amyloid Beta Plaques are Correlated with Alzheimer’s Neuropathology, Cognitive Dysfunction, and Neuroinflammation in the Human Hippocampus
por: Liu, Fan, et al.
Publicado: (2022)

On Amyloid Degeneration
Publicado: (1861)

Cerebral amyloid deposition predicts long‐term cognitive decline in hemorrhagic small vessel disease
por: Tsai, Ya‐Chin, et al.
Publicado: (2023)

Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline
por: Mehta, Neel H., et al.
Publicado: (2023)

Intrasarcolemmal Proliferation of the VX2 Carcinoma
por: Galasko, C. S. B., et al.
Publicado: (1974)

Beginning RPG Maker VX Ace
por: Perez, Darrin
Publicado: (2014)

VX-detector installation in X7
Publicado: (1998)

Amyloid Deposits in the Ligamentum Flavum Related to Lumbar Spinal Canal Stenosis and Lumbar Disc Degeneration
por: Al Yaseen, Mustafa, et al.
Publicado: (2022)

Molecular imaging of the association between serotonin degeneration and beta-amyloid deposition in mild cognitive impairment
por: Smith, Gwenn S., et al.
Publicado: (2023)

P765: MIB2/SUZ12 REGULATED THE PROLIFERATION OF PNH CLONE
por: Zeng, Lijie, et al.
Publicado: (2023)

Spatial patterns of tau deposition are associated with amyloid, ApoE, sex, and cognitive decline in older adults
por: Pereira, Joana B., et al.
Publicado: (2020)

Congenital agenesis of internal carotid artery with ipsilateral Horner presenting as focal neurological symptoms
por: Farhat, Wassim, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_nfgj0ft8i3fbfejsrihru2k4or