Live probiotic bacteria administered in a pathomimetic Leaky Gut Chip ameliorate impaired epithelial barrier and mucosal inflammation

Here, we report a pathomimetic Leaky Gut Chip that recapitulates increased epithelial permeability and intestinal inflammation to assess probiotic intervention as live biotherapeutics. We leveraged a mechanodynamic human gut-on-a-chip (Gut Chip) that recreates three-dimensional epithelial layers in...

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Detalles Bibliográficos
Autores principales: Min, Soyoun, Than, Nam, Shin, Yong Cheol, Hu, Grace, Shin, Woojung, Ambrosini, Yoko M., Kim, Hyun Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805460/
https://www.ncbi.nlm.nih.gov/pubmed/36587177
http://dx.doi.org/10.1038/s41598-022-27300-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805460/
https://www.ncbi.nlm.nih.gov/pubmed/36587177
http://dx.doi.org/10.1038/s41598-022-27300-w

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