Gene set proximity analysis: expanding gene set enrichment analysis through learned geometric embeddings, with drug-repurposing applications in COVID-19

MOTIVATION: Gene set analysis methods rely on knowledge-based representations of genetic interactions in the form of both gene set collections and protein–protein interaction (PPI) networks. However, explicit representations of genetic interactions often fail to capture complex interdependencies amo...

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Detalles Bibliográficos
Autores principales: Cousins, Henry, Hall, Taryn, Guo, Yinglong, Tso, Luke, Tzeng, Kathy T H, Cong, Le, Altman, Russ B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805577/
https://www.ncbi.nlm.nih.gov/pubmed/36394254
http://dx.doi.org/10.1093/bioinformatics/btac735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805577/
https://www.ncbi.nlm.nih.gov/pubmed/36394254
http://dx.doi.org/10.1093/bioinformatics/btac735

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