Isolation, bioassay and 3D-QSAR analysis of 8-isopentenyl flavonoids from Epimedium sagittatum maxim. as PDE5A inhibitors

BACKGROUND: As known, inhibition of phosphodiesterase 5 (PDE5) has the therapeutic effect on male erectile dysfunction (ED), and the processed folium of Epimedium sagittatum Maxim. (PFES) characterized by 8-isopentenyl flavonoids is a famous herb for treating ED. However, the main flavonoids inhibit...

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Detalles Bibliográficos
Autores principales: Li, Juntao, Wu, Yue, Yu, Xinxin, Zheng, Xinyu, Xian, Jiechen, Li, Senjie, Shi, Wanyin, Tang, Yun, Chen, Zhe-Sheng, Liu, Guixia, Yao, Shen, Xu, Jian, Zheng, Xiangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805685/
https://www.ncbi.nlm.nih.gov/pubmed/36587222
http://dx.doi.org/10.1186/s13020-022-00705-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805685/
https://www.ncbi.nlm.nih.gov/pubmed/36587222
http://dx.doi.org/10.1186/s13020-022-00705-5

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