Systemic blockade of proBDNF inhibited the expansion and altered the transcriptomic expression in CD3(+)B220(+) cells in MRL/lpr lupus mice

OBJECTIVES: The overexpansion of CD3(+)B220(+) cells is the hallmark and main pathological mechanism of clinical manifestations of spontaneously developed MRL/lpr mice, which are primarily used as a mouse model of SLE. Our recent report demonstrated that blocking brain-derived neurotrophic factor pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zha, An-Hui, Luo, Cong, Shen, Wei-Yun, Fu, Di, Dai, Ru-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Animal Models
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806060/
https://www.ncbi.nlm.nih.gov/pubmed/36581381
http://dx.doi.org/10.1136/lupus-2022-000836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806060/
https://www.ncbi.nlm.nih.gov/pubmed/36581381
http://dx.doi.org/10.1136/lupus-2022-000836

Ejemplares similares