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Systemic blockade of proBDNF inhibited the expansion and altered the transcriptomic expression in CD3(+)B220(+) cells in MRL/lpr lupus mice
OBJECTIVES: The overexpansion of CD3(+)B220(+) cells is the hallmark and main pathological mechanism of clinical manifestations of spontaneously developed MRL/lpr mice, which are primarily used as a mouse model of SLE. Our recent report demonstrated that blocking brain-derived neurotrophic factor pr...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BMJ Publishing Group
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806060/ https://www.ncbi.nlm.nih.gov/pubmed/36581381 http://dx.doi.org/10.1136/lupus-2022-000836 |