Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-A(Thr288)-geminin dual signaling pathways

Lysophosphatidic acid (LPA) and geminin are overexpressed in ovarian cancer, and increasing evidence supports their contribution to ovarian tumor development. Here, we reveal that geminin depletion induces autophagy suppression and enhances reactive oxygen species (ROS) production and apoptosis of h...

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Detalles Bibliográficos
Autores principales: Zhao, Haile, Jia, Peijun, Nanding, Kathleen, Wu, Man, Bai, Xiaozhou, Morigen, Morigen, Fan, Lifei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806123/
https://www.ncbi.nlm.nih.gov/pubmed/36601056
http://dx.doi.org/10.3389/fphar.2022.1046269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806123/
https://www.ncbi.nlm.nih.gov/pubmed/36601056
http://dx.doi.org/10.3389/fphar.2022.1046269

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