Cargando…

Cathepsin L inhibition prevents the cleavage of multiple nuclear proteins upon lysis of quiescent human cells

Several studies have indicated a role for cathepsin L (CTSL) proteolytic activity in the nucleus under distinct cellular conditions, including during differentiation, senescence, and quiescence. Here we show that addition of CTSL inhibitors to a cell lysis buffer prevents the cleavage of several nuc...

Descripción completa

Detalles Bibliográficos
Autores principales: Gaikwad, Prashant, Kemp, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807461/
https://www.ncbi.nlm.nih.gov/pubmed/36606083
http://dx.doi.org/10.17912/micropub.biology.000716