HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA‐less cancer cells

Recent comprehensive analyses of mtDNA and orthogonal RNA‐sequencing data revealed that in numerous human cancers, mtDNA copy numbers and mtRNA amounts are significantly reduced, followed by low respiratory gene expression. Under such conditions (called mt‐Low), cells encounter severe cell prolifera...

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Detalles Bibliográficos
Autores principales: Maruyama, Tsuyoshi, Saito, Koji, Higurashi, Masato, Ishikawa, Fumihiro, Kohno, Yohko, Mori, Kazunori, Shibanuma, Motoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807519/
https://www.ncbi.nlm.nih.gov/pubmed/36102493
http://dx.doi.org/10.1111/cas.15582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807519/
https://www.ncbi.nlm.nih.gov/pubmed/36102493
http://dx.doi.org/10.1111/cas.15582

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