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Spine morphogenesis and synapse formation in tubular sclerosis complex models

Tuberous sclerosis complex (TSC) is caused by mutations in the Tsc1 or Tsc2 genes, whose products form a complex and inactivate the small G-protein Rheb1. The activation of Rheb1 may cause refractory epilepsy, intellectual disability, and autism, which are the major neuropsychiatric manifestations o...

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Detalles Bibliográficos
Autores principales: Shimada, Tadayuki, Yamagata, Kanato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807618/
https://www.ncbi.nlm.nih.gov/pubmed/36606143
http://dx.doi.org/10.3389/fnmol.2022.1019343