An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses

Myxovirus resistance protein 1 (MX1) and MX2 are homologous, dynamin-like large GTPases, induced upon interferon exposure. Human MX1 (HsMX1) is known to inhibit many viruses, including influenza A virus, by likely acting at various steps of their life cycles. Despite decades of studies, the mechanis...

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Detalles Bibliográficos
Autores principales: McKellar, Joe, Arnaud-Arnould, Mary, Chaloin, Laurent, Tauziet, Marine, Arpin-André, Charlotte, Pourcelot, Oriane, Blaise, Mickaël, Moncorgé, Olivier, Goujon, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808005/
https://www.ncbi.nlm.nih.gov/pubmed/36436557
http://dx.doi.org/10.1016/j.jbc.2022.102747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808005/
https://www.ncbi.nlm.nih.gov/pubmed/36436557
http://dx.doi.org/10.1016/j.jbc.2022.102747

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