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Efficient clinical-grade γ-retroviral vector purification by high-speed centrifugation for CAR T cell manufacturing
γ-Retroviral vectors (γ-RV) are powerful tools for gene therapy applications. Current clinical vectors are produced from stable producer cell lines which require minimal further downstream processing, while purification schemes for γ-RV produced by transient transfection have not been thoroughly inv...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808014/ https://www.ncbi.nlm.nih.gov/pubmed/36620071 http://dx.doi.org/10.1016/j.omtm.2022.12.006 |