Efficient clinical-grade γ-retroviral vector purification by high-speed centrifugation for CAR T cell manufacturing

γ-Retroviral vectors (γ-RV) are powerful tools for gene therapy applications. Current clinical vectors are produced from stable producer cell lines which require minimal further downstream processing, while purification schemes for γ-RV produced by transient transfection have not been thoroughly inv...

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Detalles Bibliográficos
Autores principales: Mekkaoui, Leila, Tejerizo, Jose G., Abreu, Sara, Rubat, Lydie, Nikoniuk, Aleksandra, Macmorland, William, Horlock, Claire, Matsumoto, Sofia, Williams, Sarah, Smith, Koval, Price, Juliet, Srivastava, Saket, Hussain, Rehan, Banani, Mohammad Amin, Day, William, Stevenson, Elena, Madigan, Meghan, Chen, Jie, Khinder, Ravin, Miah, Shahed, Walker, Simon, Ade-Onojobi, Michael, Domining, Sabine, Sillibourne, James, Sabatino, Marianna, Slepushkin, Vladimir, Farzaneh, Farzin, Pule, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808014/
https://www.ncbi.nlm.nih.gov/pubmed/36620071
http://dx.doi.org/10.1016/j.omtm.2022.12.006

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