Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma

Activating KRAS mutations and functional loss of members of the SWI/SNF complex, including ARID1A, are found together in the primary liver tumor cholangiocarcinoma (CC). How these mutations cooperate to promote CC has not been established. Using murine models of hepatocyte and biliary-specific linea...

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Detalles Bibliográficos
Autores principales: Guo, Bing, Friedland, Scott C., Alexander, William, Myers, Jacquelyn A., Wang, Wenjia, O’Dell, Michael R., Getman, Michael, Whitney-Miller, Christa L., Agostini-Vulaj, Diana, Huber, Aaron R., Mello, Stephano S., Vertino, Paula M., Land, Hartmut K., Steiner, Laurie A., Hezel, Aram F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808599/
https://www.ncbi.nlm.nih.gov/pubmed/36044839
http://dx.doi.org/10.1016/j.celrep.2022.111253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808599/
https://www.ncbi.nlm.nih.gov/pubmed/36044839
http://dx.doi.org/10.1016/j.celrep.2022.111253

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