Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in type 2 diabetes mellitus and the elderly, impacting 40% of individuals over 70. Regulation of heterochromatin at the nuclear lamina has been associated with aging and age-dependent metabolic changes. We previously showed that changes at...

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Detalles Bibliográficos
Autores principales: Wei, Xiaolong, Murphy, Megan A., Reddy, Nihal A., Hao, Yi, Eggertsen, Taylor G., Saucerman, Jeffrey J., Bochkis, Irina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808618/
https://www.ncbi.nlm.nih.gov/pubmed/36522168
http://dx.doi.org/10.1101/gr.277149.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808618/
https://www.ncbi.nlm.nih.gov/pubmed/36522168
http://dx.doi.org/10.1101/gr.277149.122

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