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Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in type 2 diabetes mellitus and the elderly, impacting 40% of individuals over 70. Regulation of heterochromatin at the nuclear lamina has been associated with aging and age-dependent metabolic changes. We previously showed that changes at...

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Detalles Bibliográficos
Autores principales:	Wei, Xiaolong, Murphy, Megan A., Reddy, Nihal A., Hao, Yi, Eggertsen, Taylor G., Saucerman, Jeffrey J., Bochkis, Irina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808618/ https://www.ncbi.nlm.nih.gov/pubmed/36522168 http://dx.doi.org/10.1101/gr.277149.122

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