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Methyl-SNP-seq reveals dual readouts of methylome and variome at molecule resolution while enabling target enrichment

Covalent modifications of genomic DNA are crucial for most organisms to survive. Amplicon-based high-throughput sequencing technologies erase all DNA modifications to retain only sequence information for the four canonical nucleobases, necessitating specialized technologies for ascertaining epigenet...

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Detalles Bibliográficos
Autores principales: Yan, Bo, Wang, Duan, Vaisvila, Romualdas, Sun, Zhiyi, Ettwiller, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808626/
https://www.ncbi.nlm.nih.gov/pubmed/36332968
http://dx.doi.org/10.1101/gr.277080.122