Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function

BACKGROUND: Astrocytes are crucial for maintaining brain homeostasis and synaptic function, but are also tightly connected to the pathogenesis of Alzheimer’s disease (AD). Our previous data demonstrate that astrocytes ingest large amounts of aggregated amyloid-beta (Aβ), but then store, rather than...

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Detalles Bibliográficos
Autores principales: Konstantinidis, Evangelos, Portal, Benjamin, Mothes, Tobias, Beretta, Chiara, Lindskog, Maria, Erlandsson, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809017/
https://www.ncbi.nlm.nih.gov/pubmed/36593462
http://dx.doi.org/10.1186/s12974-022-02687-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809017/
https://www.ncbi.nlm.nih.gov/pubmed/36593462
http://dx.doi.org/10.1186/s12974-022-02687-5

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