Cargando…

Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function

BACKGROUND: Astrocytes are crucial for maintaining brain homeostasis and synaptic function, but are also tightly connected to the pathogenesis of Alzheimer’s disease (AD). Our previous data demonstrate that astrocytes ingest large amounts of aggregated amyloid-beta (Aβ), but then store, rather than...

Descripción completa

Detalles Bibliográficos
Autores principales:	Konstantinidis, Evangelos, Portal, Benjamin, Mothes, Tobias, Beretta, Chiara, Lindskog, Maria, Erlandsson, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809017/ https://www.ncbi.nlm.nih.gov/pubmed/36593462 http://dx.doi.org/10.1186/s12974-022-02687-5

Ejemplares similares

Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
por: Mothes, Tobias, et al.
Publicado: (2023)

Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism
por: Zyśk, Marlena, et al.
Publicado: (2023)

Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons
por: Hedegaard, Anne, et al.
Publicado: (2020)

Aberrant iPSC-derived human astrocytes in Alzheimer's disease
por: Jones, V C, et al.
Publicado: (2017)

Mass spectrometry analysis of tau and amyloid‐beta in iPSC‐derived models of Alzheimer’s disease and dementia
por: Arber, Charles, et al.
Publicado: (2021)

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques
por: Preman, Pranav, et al.
Publicado: (2021)

Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation
por: Zhou, Shuling, et al.
Publicado: (2016)

Correction: Aberrant iPSC-derived human astrocytes in Alzheimer’s disease
por: Jones, V. C., et al.
Publicado: (2019)

MS‐Driven Metabolic Alterations Are Recapitulated in iPSC‐Derived Astrocytes
por: Ghirotto, Bruno, et al.
Publicado: (2022)

Preparation and Co‐Culture of iPSC‐Derived Dopaminergic Neurons and Astrocytes
por: de Rus Jacquet, Aurelie
Publicado: (2019)

Comparison of two protocols for the generation of iPSC-derived human astrocytes
por: Mulica, Patrycja, et al.
Publicado: (2023)

Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes
por: Patel, Abdulsamie M., et al.
Publicado: (2019)

Astrocytes Attenuate Mitochondrial Dysfunctions in Human Dopaminergic Neurons Derived from iPSC
por: Du, Fang, et al.
Publicado: (2018)

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation
por: Spreng, Anna-Sophie, et al.
Publicado: (2022)

Applications of iPSC-derived beta cells from patients with diabetes
por: Maxwell, Kristina G., et al.
Publicado: (2021)

Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons
por: Robbins, Jacqueline P., et al.
Publicado: (2018)

Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons
por: Allison, Reilly L., et al.
Publicado: (2022)

Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates
por: Rostami, Jinar, et al.
Publicado: (2021)

Human iPSC-Derived Astrocytes: A Powerful Tool to Study Primary Astrocyte Dysfunction in the Pathogenesis of Rare Leukodystrophies
por: Lanciotti, Angela, et al.
Publicado: (2021)

Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia
por: Bassil, Reina, et al.
Publicado: (2021)

Isolation of Human CD49f(+) Astrocytes and In Vitro iPSC-Based Neurotoxicity Assays
por: Barbar, Lilianne, et al.
Publicado: (2020)

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects
por: Mansur, Fernanda, et al.
Publicado: (2021)

Autophagy-Mediated Inflammatory Cytokine Secretion in Sporadic ALS Patient iPSC-Derived Astrocytes
por: BaofengFeng,, et al.
Publicado: (2022)

An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis
por: Talvio, Karo, et al.
Publicado: (2023)

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease
por: Oksanen, Minna, et al.
Publicado: (2017)

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease
por: di Domenico, Angelique, et al.
Publicado: (2019)

Generation of Human iPSC-Derived Astrocytes with a mature star-shaped phenotype for CNS modeling
por: Voulgaris, Dimitrios, et al.
Publicado: (2022)

Banking on iPSC- Is it Doable and is it Worthwhile
por: Solomon, Susan, et al.
Publicado: (2014)

Roadblocks in the Path of iPSC to the Clinic
por: Garreta, Elena, et al.
Publicado: (2018)

iPSC Bioprinting: Where are We at?
por: Romanazzo, Sara, et al.
Publicado: (2019)

Maturing iPSC-Derived Cardiomyocytes
por: Tang, Bor Luen
Publicado: (2020)

iPSC for modeling neurodegenerative disorders
por: Valadez-Barba, Valeria, et al.
Publicado: (2020)

Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia
por: Aldana, Blanca I., et al.
Publicado: (2020)

Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
por: Reyes-Ortiz, Andrea M., et al.
Publicado: (2022)

iPSC-derived reactive astrocytes from patients with multiple sclerosis protect cocultured neurons in inflammatory conditions
por: Kerkering, Janis, et al.
Publicado: (2023)

The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation
por: Vethe, Heidrun, et al.
Publicado: (2019)

Oligomeric amyloid-β induces early and widespread changes to the proteome in human iPSC-derived neurons
por: Sackmann, Christopher, et al.
Publicado: (2020)

iPSC-based model of viral infection
Publicado: (2012)

Chromatin looping is needed for iPSC induction
por: Hu, Ji-Fan, et al.
Publicado: (2014)

iPSC-MSCs and islet allograft tolerance
por: Wang, Tong-Song, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_jma1ad5gfefricpi67lkacqiet