Enhanced control of bioactivity of tissue plasminogen activator (tPA) through domain-directed enzymatic oxidation of terminal galactose

[Image: see text] Introduction: In targeted enzyme prodrug constructs, it is critical to control the bioactivity of the drug in its prodrug form. The preparation of such constructs often involves conjugation reactions directed to functional groups on amino acid side chains of the protein, which resu...

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Detalles Bibliográficos
Autores principales: Mahdi, Wael A., Absar, Mohammad S., Choi, Suna, Yang, Victor C., Kwon, Young M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences (TUOMS Publishing Group) 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809136/
https://www.ncbi.nlm.nih.gov/pubmed/36644546
http://dx.doi.org/10.34172/bi.2022.23477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809136/
https://www.ncbi.nlm.nih.gov/pubmed/36644546
http://dx.doi.org/10.34172/bi.2022.23477

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