Aβ oligomers from human brain impair mossy fiber LTP in CA3 of hippocampus, but activating cAMP-PKA and cGMP-PKG prevents this

Early cognitive impairment in Alzheimer’s disease may result in part from synaptic dysfunction caused by the accumulation oligomeric assemblies of amyloid β-protein (Aβ). Changes in hippocampal function seem critical for cognitive impairment in early Alzheimer’s disease (AD). Diffusible oligomers of...

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Detalles Bibliográficos
Autores principales: Jin, Shan-Xue, Liu, Lei, Li, Shaomin, Meunier, Angela L., Selkoe, Dennis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809147/
https://www.ncbi.nlm.nih.gov/pubmed/35820646
http://dx.doi.org/10.1016/j.nbd.2022.105816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809147/
https://www.ncbi.nlm.nih.gov/pubmed/35820646
http://dx.doi.org/10.1016/j.nbd.2022.105816

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