Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells

Mitochondrial dysfunction, a hallmark of aging, has been associated with the onset of aging phenotypes and age-related diseases. Here, we report that impaired mitochondrial function is associated with increased glutamine catabolism in senescent human mesenchymal stem cells (MSCs) and myofibroblasts...

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Detalles Bibliográficos
Autores principales: Choudhury, Debanik, Rong, Na, Ikhapoh, Izuagie, Rajabian, Nika, Tseropoulos, Georgios, Wu, Yulun, Mehrotra, Pihu, Thiyagarajan, Ramkumar, Shahini, Aref, Seldeen, Kenneth L., Troen, Bruce, Lei, Pedro, Andreadis, Stelios T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809151/
https://www.ncbi.nlm.nih.gov/pubmed/36450260
http://dx.doi.org/10.1016/j.celrep.2022.111744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809151/
https://www.ncbi.nlm.nih.gov/pubmed/36450260
http://dx.doi.org/10.1016/j.celrep.2022.111744

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