CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses

BACKGROUND: To date, T cells redirected with CD19-specific chimeric antigen receptors (CAR) have gained impressive success in B-cell malignancies. However, treatment failures are common and the occurrence of severe toxicities, such as cytokine release syndrome (CRS), still limits the full exploitati...

Descripción completa

Detalles Bibliográficos
Autores principales: Bove, Camilla, Arcangeli, Silvia, Falcone, Laura, Camisa, Barbara, El Khoury, Rita, Greco, Beatrice, De Lucia, Anna, Bergamini, Alice, Bondanza, Attilio, Ciceri, Fabio, Bonini, Chiara, Casucci, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809278/
https://www.ncbi.nlm.nih.gov/pubmed/36593069
http://dx.doi.org/10.1136/jitc-2022-005878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809278/
https://www.ncbi.nlm.nih.gov/pubmed/36593069
http://dx.doi.org/10.1136/jitc-2022-005878

Ejemplares similares