Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity

BACKGROUND: Agonistic anti-CD40 monoclonal antibodies (mAbs) have emerged as promising immunotherapeutic compounds with impressive antitumor effects in mouse models. However, preclinical and clinical studies faced dose-limiting toxicities mediated by necroinflammatory liver disease. An effective pro...

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Detalles Bibliográficos
Autores principales: Pfefferlé, Marc, Dubach, Irina L, Buzzi, Raphael M, Dürst, Elena, Schulthess-Lutz, Nadja, Baselgia, Livio, Hansen, Kerstin, Imhof, Larissa, Koernig, Sandra, Le Roy, Didier, Roger, Thierry, Humar, Rok, Schaer, Dominik J, Vallelian, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809320/
https://www.ncbi.nlm.nih.gov/pubmed/36593065
http://dx.doi.org/10.1136/jitc-2022-005718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809320/
https://www.ncbi.nlm.nih.gov/pubmed/36593065
http://dx.doi.org/10.1136/jitc-2022-005718

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