Loss of MiR-155 Sensitizes FLT3-ITD(+)AML to Chemotherapy and FLT3 Inhibitors via Glycolysis Blocking by Targeting PIK3R1

FLT3 tyrosine kinase inhibitors in combination with chemotherapy have shown some success in patients with FLT3 mutations. But a variety of mechanisms have led to the rapid resistance to the treatment. One of the most prominent is the metabolic alteration on aerobic glycolysis. We aim to explore the...

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Detalles Bibliográficos
Autores principales: Wang, Lingyan, Jiang, Peifang, Li, Jiazheng, Huang, Yan, Wen, Jingjing, Wu, Zhengjun, Chen, Yanxin, Hu, Jianda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809327/
https://www.ncbi.nlm.nih.gov/pubmed/36605494
http://dx.doi.org/10.7150/jca.54775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809327/
https://www.ncbi.nlm.nih.gov/pubmed/36605494
http://dx.doi.org/10.7150/jca.54775

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