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Loss of MiR-155 Sensitizes FLT3-ITD(+)AML to Chemotherapy and FLT3 Inhibitors via Glycolysis Blocking by Targeting PIK3R1
FLT3 tyrosine kinase inhibitors in combination with chemotherapy have shown some success in patients with FLT3 mutations. But a variety of mechanisms have led to the rapid resistance to the treatment. One of the most prominent is the metabolic alteration on aerobic glycolysis. We aim to explore the...
Autores principales: | Wang, Lingyan, Jiang, Peifang, Li, Jiazheng, Huang, Yan, Wen, Jingjing, Wu, Zhengjun, Chen, Yanxin, Hu, Jianda |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809327/ https://www.ncbi.nlm.nih.gov/pubmed/36605494 http://dx.doi.org/10.7150/jca.54775 |
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